Capillary for continuous glucose monitoring
| German title: | Kapillare zum kontinuierlichen Glukosemonitoring | |
| Acronym: | µKAP | |
| Duration: | 1st February 2015 - 30th September 2016 | |
| Description: | Porous, thin-walled filters (membranes) allow energy-saving separation of substances without the need for additional chemicals. Membranes made of inorganic materials, such as metal and ceramics, can also be used under harsh conditions (temperature, pressure, chemical or abrasive attack), are easy to clean and also to sterilize, and are too mostly biocompatible. Until now, inorganic membranes have been manufactured almost exclusively from metallic or ceramic powders by extrusion, pressing or film drawing with subsequent sintering and multiple coating. These processes are labor- and energy-intensive and allow only a few geometries (tubes of constant diameter and wall thickness, homogeneous discs, disc stacks (filter pockets)) with a small filter area per element. In the application, the inorganic membranes must be sealed in a pressure-stable manner at great expense, and a tight joint must be made to other sensor components. Sealing or joining materials can usually only be made from polymer materials, which severely limits the advantage of inorganic membranes. Additive manufacturing allows metallic membranes of almost any geometry to be manufactured in parallel and thus in large quantities. Geometries with large specific membrane areas, including undercuts, deflections and constrictions, are possible. Filigree structures can be produced. Non-porous, dense inlets and outlets can be created in the same manufacturing step, enabling subsequent metallic bonding of the membranes to a sensor unit. Subsequent coating with porous ceramic materials via slurry and sol-gel techniques can open up the field of meso- and microporous membranes for mass separation in chemical, pharmaceutical, water and wastewater treatment sensor applications. In the µKap project, a miniaturized microporous measuring chamber for an optically operating sensor for continuous glucose monitoring (diabetes mellitus) is being developed and manufactured. An iterative process results in a "scientifically" validated system design. The further development of the layer manufacturing technology created approaches to be able to realize the requirements placed on the cannulas. To this end, efficient layer-based software was developed that eliminates the disadvantages of CAD or STL models for sophisticated added manufacturing. An efficient layer structure was created from a special combination of solid model and grid structure. On this basis, a final system design was implemented and evaluated according to statistical methods with respect to the tolerance specifications. The results achieved secure CiS and Realizer a worldwide technology leadership. |
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| Funded by: | ||
| Funding code: | KF2020412MS4 | |
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